Ketamine works by interacting with specific receptors in the brain, primarily the NMDA receptor, which plays a key role in regulating glutamate, a neurotransmitter involved in learning and memory. By blocking this receptor, ketamine alters brain communication and promotes rapid changes in neural activity. This action leads to increased levels of other neurotransmitters, like glutamate and brain-derived neurotrophic factor (BDNF), which support neural growth and connectivity.